B-1 B Cell Development in the Fetus and Adult

B - 1 B Cell Development 1

B - 1 B Cell Development 1 Richard

B - 1 Cell Development : Evidence for an Uncommitted Immunoglobulin ( Ig ) M 1 B Cell Precursor in B - 1 Cell Differentiation

Murine phosphatidyl choline (PtC)–specific B cells in normal mice belong exclusively to the B-1 subset. Analysis of anti-PtC (V H 12 and V H 12/V k 4) transgenic (Tg) mice indicates that exclusion from B-0 (also known as B-2) occurs after immunoglobulin gene rearrangement. This predicts that PtC-specific B-0 cells are generated, but subsequently eliminated by either apoptosis or differentiation...

Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells

The transcription factor Foxp1 is critical for early B cell development. Despite frequent deregulation of Foxp1 in B cell lymphoma, the physiological functions of Foxp1 in mature B cells remain unknown. Here, we used conditional gene targeting in the B cell lineage and report that Foxp1 disruption in developing and mature B cells results in reduced numbers and frequencies of follicular and B-1 ...

B-1 Cell Development and Function

Coelomic cavity-derived B-1 and splenic marginal zone (MZ) B lymphocytes play principal roles in frontline host protection at homeostasis and during primary humoral immune responses. Although they share many features that enable rapid and broad-based defense against pathogens, these innate-like subsets have disparate B cell receptor (BCR) signaling features. Members of the Fc receptor-like (FCR...